The brain is the control for the neuromusculoskeletal system. Some evidence points to oxidative stress causing inflammation in the brain with damage to the brain cells. Ongoing inflammation inhibits regeneration and neuroplasticity of new brain cells. Activating resident metabolics that can differentiate then transmigrate by traveling to restore the brain function may be a key solution. The downstream effects of brain inflammation affect the neuromuscular skeletal complexes in various ways. Inflammation of these systems are directly correlated with the vertebral subluxation complex.